Baby's on roller skates

Just another gynecological obstetric site


Leave a comment

Unexplained fertility, do you even consider about IVF? Where the border stands?

Nearly 80% of the couples that are trying to have a baby suffer from unexplained infertility. This is a message that has been sent from the Queen’s University Belfast and it has been published in the journal Reproductive Biomedicine Online.
According to this report there are 1 million couples worldwide that undergo fertility treatments every year. We may have heard about that on the daily news, but we didn’t know that one third of them are told about the unexplained infertility problem that they have. This actually means that doctors cannot explain what is wrong and why they cannot have a baby. It is a huge problem among all young couples that are desperately seeking ways to have a baby.
If you have an unexplained infertility, do you even consider about IVF? Where the border stands? Simple explanation about those borders
This so called border stand right into the women age, how long have they been trying to have a baby, and if the woman have been pregnant before and had her first child. This is a border that explains everything. From personal experience I have seen many couples that have been trying to have a baby. Yes most of them were diagnosed with unexplained infertility which is quite often these days. There is something that I and my colleagues cannot understand. It is about why people and I are talking about young couples about 22-24 years all are disappointed. Usually they are disappointed after trying in the first month. They should not be disappointed because they are too young and they haven ben trying too long. That is why the doctors say that you have to be married for three years and then try all the methods for getting pregnant. Starting with IVF too early is not such a great solution unless you are 35 years old and have been trying in the past three or four years. It is understandable that doctors recommend the less invasive and cheaper methods before starting the in vitro fertilization process, which is $12,000 per cycle, but with those methods the doctors are making a huge disservice. When we talk about those women that are under 35 could be better off trying to get pregnant on their own. This is only at least for the next few months. As for women that are older than 35, it is better to avoid wasting their precious time and straight ahead to IVF or consider about the adoption options.
Just trust yourself
Having always irregular periods, which means twice a year the chances of ever getting pregnant are too small. Doctors in these cases often prescribe Clomid in order to induce ovulation. Most doctors do not recommend, but Provera has done miracles in some infertility cases. Women that are 40 years old have a chance for getting pregnant despite their age. Unexplained infertility, do you even consider IVF? Where the border stands? Having a good doctor that believes in you can help in these situations. It is actually the most important thing. No matter how far that doctor is you have to find him and take your chances.


Leave a comment

Before IVF- More about the fertility drugs

Generally, fertility drugs are used to treat problems with ovulation or recurrent miscarriage. However, this is not always the case, so even if you’re using assisted reproductive techniques such as IVF (in vitro fertilization), fertility drugs are still an important part of treatment. In this case, fertility drugs may increase the number of eggs the women produces. Some are taken orally, and some are injected. What do these wonder pills and injections do? In general, these medications work by causing the release of hormones that either trigger or regulate ovulation. Fertility drugs can also be used in men to treat male factor infertility, but this is less common.

Commonly Prescribed Fertility Drugs

Since the number and names of all of the infertility medications may seem dizzying, here are the basic facts on the drugs most commonly prescribed.

  • Clomiphene
    Clomiphene is usually the first choice for treating infertility, because it is effective. Clomiphene works by stimulating hormones in your brain (hypothalamus and pituitary gland) to release hormones like GnRH (gonadotropin releasing hormone), FSH (follicle stimulating hormone), and LH (luteinizing hormone) – that will stimulate the ovaries to produce egg (or several) each month, while gonadotropins stimulate your ovaries directly to produce an egg (or several). That’s all some women need to get pregnant.
  • Gonadotropins
    Brand names: Pergonal, Repronex, Fertinex, Follistim, Gonal F, Novarel, Ovidrel, Pregnyl, Profasi, and Menogon and Puregon (available only in Europe). These drugs are meant to mimic the LH hormone in the body, LH triggers ovulation. And sometimes they are combined with FSH treatment, also known as human menopausal gonadotropins (hMG), but this may be used in some special cases, not that requently. They are injectables.

But like many other fertility solutions, such as in vitro fertilization, fertility drugs can increase your chance of multiple births — and the more babies you carry, the greater your risk for complications such as miscarriage and premature labor. About 10 percent of women who take Clomid have multiples (mostly twins), as do 10 to 40 percent of women who take gonadotropins.

Risks of Fertility Drugs

As with the use of any drug, risks come with fertility drugs. One risk you’re no doubt familiar with is the risk of a multiple pregnancy. Multiples, either twins, triplets, or higher-order, can occur when using fertility drugs.  The side effects of clomiphene are generally mild. They include hot flashes, blurred vision, nausea, bloating, and headache. Clomid can also cause changes in the cervical mucus, which may make it harder to tell when you’re fertile and may inhibit the sperm from entering the uterus.

Another potential side effect of fertility drug use is ovarian hyperstimulation syndrome, or OHSS. OHSS happens when the ovaries are overly stimulated, becoming dangerously large and filled with too much fluid. This fluid, which is released with ovulation, can lead to serious complications. OHSS is rarely life threatening, but it should be taken seriously.


9 Comments

Before IVF- What is intrauterine insemination?

What is IUI?

Intrauterine insemination (IUI) involves a laboratory procedure to separate fast moving sperm from more sluggish or non-moving sperm.The fast moving sperm are then placed into the woman’s womb close to the time of ovulation when the egg is released from the ovary in the middle of the monthly cycle.

Is IUI for me?

Your doctor may recommend IUI if:

  • there is unexplained infertility
  • there are ovulation problems
  • the male partner experiences impotence or low sperm count or decreased sperm mobility
  • you do not have any known fertility problems but may not have a male partner and are trying for a baby using donated sperm.
  • Ejaculation dysfunction

 

In sum, IUI is a reasonable therapy for some infertility patients, but should be abandoned for IVF by the end of the third IUI cycle.

It is essential that your fallopian tubes are known to be open and healthy before the IUI process begins, because one of the most common causes of infertility is blockage of the fallopian tubes. A tubal patency test is usually carried out as part of your assessment by the fertility clinic. When the pelvis and tubes are healthy, dye passes freely through both tubes. There should be no adhesions present that might prevent an egg from having access to either tube from the ovaries.

 

The second essential requirement is that there is no significant problem with sperm numbers or sperm quality. If your partner is unable to provide sperm, or if you do not have a male partner, you may want to consider donated sperm.

 

How does IUI work?

For women:

  • If you are not using fertility drugs IUI is done between day 12 and day 16 of your monthly cycle – with day one being the first day of your period. You are given blood or urine tests to identify when you are about to ovulate. Many clinics will provide you with an ovulation predictor kit to detect the hormone surge that signals imminent ovulation.

– or –

If you use fertility drugs to stimulate ovulation, vaginal ultrasound scans are used to track the development of your eggs. As soon as an egg is mature, you are given a hormone injection to stimulate its release.

You should consider the best option for you with your doctor.

 

  •  The sperm are inserted 36 to 40 hours later. To do this, the doctor first  inserts a speculum (a special instrument that keeps your vaginal walls apart) into your vagina.

A small catheter (a soft, flexible tube) is then threaded into your womb via your cervix. The best quality sperm are selected and inserted through the catheter.

The whole process takes just a few minutes and is usually a painless procedure but some women may experience a temporary, menstrual-like cramping.

  • You may want to rest for a short time before leaving the clinic – ask your clinic what they recommend.

 

For men:

  • You will be asked to produce a sperm sample on the day the treatment takes place.
  • The sperm are washed to remove the fluid surrounding them and the rapidly moving sperm separated out.
  • The rapidly moving sperm are placed in a small catheter (tube) to be inserted into the womb.


Leave a comment

Getting ready for IVF- what is reproductive immunology?

“In the 1980s, it became clear to me that products of an activated immune system could damage the placenta and cause miscarriage, as well damage the embryo and cause implantation failure. Natural killer cells, which help to keep the body from developing cancer, can over-populate the uterus or exist at too high levels within the blood stream. These cells than go overboard, killing the embryo or interfering with the endocrine system that produces the hormones that are essential for pregnancy. This response can often be associated with complications for both the mother and her baby if the pregnancy occurs without treatment to suppress the activity of the immune system“.  – Dr. Alan E. Beer (“Is Your Body Baby Friendly?”)

Dr. Alan E. Beer is widely considered as the pioneer in the field of reproductive immunology, he believes that it is not simply due to back luck that some women fail to conceive or have repeated pregnancy failure.

If you have a complex medical and fertility history, and failed fertility treatments, you might want to consider making further tests in advice with your doctor for your immune system. If you have repeated miscarriages, some doctors think that your immune system may be rejecting your pregnancy. So in normal pregnancy, it is thought that your body does something to stop the fetus being rejected. However, there is no convincing evidence that immune rejections of the fetus does actually ever happen in women with fertility problems.

summary of the most relevant testing:

  • Antiphospholipid Antibodies (APA). These are the glue molecules for implantation and placentation.
  • Antinuclear Antibodies (ANA). Some women develop antibodies to the baby’s DNA or DNA breakdown products and this problem is reflected by a positive Anti-nuclear antibody test (ANA). This is often with a speckled pattern. We also advise that women have testing to double-stranded DNA, single-stranded DNA, polynucleotides and histones.
  • Elevated CD 56+ Natural Killer Cells. This test determines the killing power of a woman’s Natural Killer Cells in the test tube. Elevated NK numbers and/or NK activity can be associated with increased risk for infertility and loss.
  • Th1/Th2 Cytokines (chemical messengers in the blood). The immune system is balanced between a TH1 (autoimmune) and TH2 (pregnancy or suppressive response). TH1 predominance can also be associated with reproductive failure. The Th1 Th2 Assay can help to determine a patient’s risk for this problem.
  • T regulatory cells (Treg). Higher numbers of Tregs in the blood have been associated with better pregnancy outcome.
  • Thrombophilias . Thrombophilia is increased tendency to clot.Throughout an entire normal pregnancy, the mother’s ability to produce blood clots in the uterus and the placenta is suppressed. However, in some mothers, this clotting tendency is not suppressed sufficiently. This can contribute to many pregnancy complications.
  • CD57 cells in the endometrium. High levels of CD57+ cells may be associated with increased risk of infertility and loss.

From your circumstances, and medical history, your consultants aim to advice you on the most appropriate tests and treatments for you. Depending on the tests results you will get appropriate immune treatments and medications.

What should I ask my doctor?

If you are recommended immunological treatments as part of your fertility treatment, we advise you to make sure you feel properly informed about the potential benefits and risks of the tests and treatment.

Your clinic should explain:

  • why they think the tests and treatment may help you
  • what the risks and side effects may be
  • the costs you will incur.

 


Leave a comment

10 proven sperm killers

Want to get pregnant? First you have to know about the 10 proven sperm killers and be prepared for all the things that can go wrong.

Trying to get pregnant is not as easy as everyone think it is. There are lots of things that can go wrong like sperm allergies, poor egg quality and ineffective sperm.  It is proven that one in ten couples are infertile.

Men produce millions of sperm a day. This millions of sperm are nothing compared to the 300-400 eggs that women release during their lifetime. However there are some external factors that can affect the health of these little swimmers. Temperature is one of the reasons that can have big influence on these swimmers, but as we know the sperm cells take about 75 days to grow to maturity. This can also affect your fertility. Check out the 10 proven sperm killers, you might be surprised knowing what may affect a man’s sperm:

High temperature

The function of the human testes is strongly connected with overheating. In order for the human testes not become overheated they need to stay cooler than the rest of the body. The nature has done miracle with this area, male anatomy is designed to create a distance between the testes and the core body temperature. It well known that if the temperature of the testicles is raised to 98 degrees than the sperm production is interrupted. Overheating of the testicles and interrupted sperm production can have a negative impact for months.

Hot tub relaxation

There are times when myths become reality. One of those cases is the influence of the hot tubes and Jacuzzi over the sperm production. More than 30 minutes in a hot tub or in a Jacuzzi can temporarily decrease the sperm production? Now how can that be true?

It is because of the wet heat exposure. If a man exposes himself to a wet heat, it may have an impact on his sperm for a long time. A man’s sperm takes long time to mature, and if he does anything that will reduce this time, it may take six to nine months to show any benefit.

High fever

If there is anything that is most similar and has the same impact to the man sperm, than it is for sure that we are talking about the high fever’s impact on a man’s sperm. It gives the same lasting effects. Generally it depends on the timing in the sperm production process, but the sperm concentration can degrease up to 35% following a fewer.

Laptops

Leave the laptop on the desk? If you are trying to conceive, you have to know that there is a direct correlation between the laptop use and increased scrotum temperature.  This increase has a harmful effect on the spermatogenesis.

 

Boxers are better than Briefs

Yes, boxers are better than briefs, but why? It is because if the man is wearing tight bicycle shorts for a long period of time this may affect if the sperm count is on the low side. If the sperm count is normal than it probably affect, but very little.

Enlarged varicose veins

Nearly 15% of men have varicoceles, or enlarged varicose veins in the scrotum. This varicocele veins are usually in the left testicle. With a low sperm count, you may think of a procedure that repairs enlarged varicose veins.

Cell phones

It is better for man to carry their phones is their briefcases rather than in their pockets. If you carry your cell phone in your pocket more than four hours per day, than you may be facing with a lower sperm count in future.

Obesity

According to the World Health Organization, obese fertile men have reduced testicular function and significantly lower sperm count. Obesity reduces the sperm count and only in some cases obesity may have a negative influence on the male reproductive potential.

Lifestyle

It is recommended for those that want to conceive to avoid tobacco, alcohol and marijuana; it can affect the semen quality, production and sperm’s motility.

Other factors

Anti-sperm antibodies, testicular cancer, hormonal imbalance and sexual problems are few of the most dangerous sperm killers.

 

 

 

 


Leave a comment

40 are the new 30?

Wait, what? 40? Really? Aging really is a state of mind, women in their 40s are looking and feeling better than ever!

Who really buys this idea of 40 being the new 30? As it turns out, women more so than men. In a recent poll, twice as many women vs. men think that 40 is the new 30.

Who doesn’t buy this idea? Not surprisingly, people who have not yet turned 30 definitely don’t think that 40 is the new 30.

We are living faster, getting married later, and having children a decade (or more) later than prior generations. Due to technological innovations and advances in science and medicine, we are improving our health and as a consequence, prolonging our lives. What this means according to scientists, is that middle age is coming on later. But also there is the fact that our body is changing, and we are getting tired easily when we are in our 40s, and we are seeing more of the lines and wrinkles on our faces. So what we should do?

We can magnify imperfections that other people don’t even see, and we should start by not obsessing over everything. We must stop comparing ourselves with other women in general, especially those that we see in the magazines. We are all different and unique, and we must focus on what makes us happy and better, and start focusing on how to take better care of ourselves. Replace the negative remarks with positive, and you will see how amazing you will feel through each day.

Many people become depressed when they hit the big 40, but contary to popular belief, there’s no real reason to fear age 40. It is becoming accepted that a person of this age has fewer limitations with regards to health and lifestyle options than those of previous generations.  People are living longer lives and, with proper lifestyle changes, can be as healthy, fit and vital, not to mention youthful in appearance and physique, for many of these years. All of this posturing to be a decade younger? Are we obsessed with looking and being young? Of course we are. And, there are billion dollar cosmetics, health and fitness industries to prove it. At some point we’ll all come to the grips of aging, it is inevitable, but we should embrace it and make that our strength because with age comes wisdom and grace. We are learning how to get more comfortable in our skin, to focus on what is important in our lives and what makes us happy.
This idea of an older decade being the ‘new’ younger decade is not a novel concept. It was first tossed years ago when stars like Sheryl Crow, Courtney Cox and Sarah Jessica Parker turned the big 40. Now that more of our most adorable starlets–Gwen Stefani, Jennifer Lopez, Jennifer Aniston, Renee Zellweger and Taraji Henson, along with many of our leading men–Matt Damon, Vince Vaughn, Tyson Beckford, Ethan Hawke, and Malcolm Jamal Warner–have hit that number in the last couple of years, Hollywood, the fashion industry, the media and, yes, the world are rethinking the way we look at those over 40.

Maybe that explains it. It’s all a matter of perspective or is this just our way of making aging more acceptable? What do you think?